After provisioning and starting the User Profile Synchronization Service: Under services FIM Started: You click on User Profile Service Application: You create a new User Profile Service Application and try browsing to the Manage link for the User Profile Service Application, this page might fail with the following error, If you filter on the "User Profiles" category in the ULS Logs, you should see these errors: UserProfileServiceUserStatisticsWebPart:LoadControl failed, Exception: System.IO.FileLoadException: The located assembly's manifest definition does not match the assembly reference. (Exception from HRESULT: 0x80131040) at Microsoft.Office.Server.UserProfiles.UserProfileConfigManager.InitializeIlmClient(String ILMMachineName, Int32 FIMWebClientTimeOut) at Microsoft.Office.Server.UserProfiles.UserProfileConfigManager..ctor(UserProfileApplicationProxy userProfileApplicationProxy, Guid partitionID) at Microsoft.SharePoint.Portal.WebControls.UserProfileServiceSta...